abstract：:Bone Morphogenetic Proteins (BMPs) are potent growth factors belonging to the Transforming Growth Factor Beta superfamily. To date over 20 members have been identified in humans with varying functions during processes such as embryogenesis, skeletal formation, hematopoiesis and neurogenesis. Though their functions hav...

journal_title：Cellular signalling

authors： Bragdon B,Moseychuk O,Saldanha S,King D,Julian J,Nohe A

更新日期：2011-04-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs) can engage multiple pathways to activate ERK1/2 via both G proteins and/or ßarrestin. Receptor recruitment of ßarrestin is also important for GPCR desensitization, internalization and resensitization. Modulation of the receptor/ßarrestin interaction through modification of either co...

journal_title：Cellular signalling

authors： Zimmerman B,Simaan M,Akoume MY,Houri N,Chevallier S,Séguéla P,Laporte SA

更新日期：2011-04-01 00:00:00

abstract：:The nuclear factor kappa B (NF-κB) transcription factor-mediated transcription is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli. Both the proteolytic and non-proteolytic functions of ubiquitination are critically important for the regulation of NF-κB activation. L...

journal_title：Cellular signalling

authors： Fan Y,Yu Y,Mao R,Zhang H,Yang J

更新日期：2011-04-01 00:00:00

abstract：:In humans, thromboxane (TX) A₂ signals through the TPα and TPβ isoforms of its G-protein coupled TXA₂ receptor (TP) to mediate a host of (patho)physiologic responses. Herein, angio-associated migratory cell protein (AAMP) was identified as a novel interacting partner of both TPα and TPβ through an interaction dependen...

journal_title：Cellular signalling

authors： Reid HM,Wikström K,Kavanagh DJ,Mulvaney EP,Kinsella BT

更新日期：2011-04-01 00:00:00

abstract：:The Reelin-Disabled 1 (Dab1) signaling pathway plays an important role in neuronal cell migration during brain development. Dab1, an intracellular adapter protein which is tyrosine phosphorylated upon Reelin stimulation, has been directly implicated in the transmission and termination of Reelin-mediated signaling. Two...

journal_title：Cellular signalling

authors： Gao Z,Godbout R

更新日期：2011-03-01 00:00:00

abstract：:Overcoming de novo and acquired resistance to anticancer drugs that target signaling networks is a formidable challenge for drug design and effective cancer therapy. Understanding the mechanisms by which this resistance arises may offer a route to addressing the insensitivity of signaling networks to drug intervention...

journal_title：Cellular signalling

authors： Goltsov A,Faratian D,Langdon SP,Bown J,Goryanin I,Harrison DJ

更新日期：2011-02-01 00:00:00

abstract：:Inflammatory stimulus during development increases the risk for adverse neurologic outcome. One possible mechanism is disrupting neuronal migration. Using lipopolysaccharide (LPS)-treatment to assess inflammatory stimulus on neuronal migration of cerebellar granule neurons, we previously found that LPS-activation incr...

journal_title：Cellular signalling

authors： Arias-Salvatierra D,Silbergeld EK,Acosta-Saavedra LC,Calderon-Aranda ES

更新日期：2011-02-01 00:00:00

abstract：:The activity of matrix metalloproteinases (MMPs), which selectively degrades the extracellular matrix (ECM), is critical in angiogenesis. Conversely, changes in ECM composition/structure alter the expression and activity of MMPs in various cell types. In the present study, we examined whether changes in ECM compositio...

journal_title：Cellular signalling

authors： Jin YJ,Park I,Hong IK,Byun HJ,Choi J,Kim YM,Lee H

更新日期：2011-01-01 00:00:00

abstract：:The human NPY Y(1) receptor undergoes fast agonist-induced internalization via clathrin-coated pits then recycles back to the cell membrane. In an attempt to identify the molecular determinants involved in this process, we studied several C-terminal truncation mutants tagged with EFGP. In the absence of agonist, Y(1) ...

journal_title：Cellular signalling

authors： Lecat S,Ouédraogo M,Cherrier T,Noulet F,Rondé P,Glasser N,Galzi JL,Mely Y,Takeda K,Bucher B

更新日期：2011-01-01 00:00:00

abstract：:Protein kinase and phosphatase signaling cascade, coupled with other post-translational modifications, orchestrates temporal order of various events during cell division. Among the many mitotic kinases, Polo-like kinase 1 (PLK1) as a key regulator, participates in regulating mitosis from mitotic entry to cytokinesis. ...

journal_title：Cellular signalling

authors： Yuan K,Huang Y,Yao X

更新日期：2011-01-01 00:00:00

abstract：:The focal adhesion kinase Pyk2 integrates signals from cell adhesion receptors, growth factor receptors, and G-protein-coupled receptors leading to the activation of intracellular signaling pathways that regulate cellular phenotypes. The intrinsic mechanism for the activation of Pyk2 activity remains to be fully defin...

journal_title：Cellular signalling

authors： Riggs D,Yang Z,Kloss J,Loftus JC

更新日期：2011-01-01 00:00:00

abstract：:The p75 neurotrophin receptor (p75(NTR)) plays a critical role in various neuronal and non-neuronal cell types by regulating cell survival, differentiation and proliferation. To evaluate the influence of p75(NTR) in breast cancer development, we have established and characterized breast cancer cells which stably overe...

journal_title：Cellular signalling

authors： Verbeke S,Meignan S,Lagadec C,Germain E,Hondermarck H,Adriaenssens E,Le Bourhis X

更新日期：2010-12-01 00:00:00

abstract：:Ras proteins function as molecular switches that are activated in response to signalling pathways initiated by various extracellular stimuli and subsequently bind to numerous effector proteins leading to the activation of several signalling cascades within the cell. Ras and Ras-related proteins belong to a large super...

journal_title：Cellular signalling

authors： Ferro E,Trabalzini L

更新日期：2010-12-01 00:00:00

abstract：:It is well established that the IFN-gamma/STAT1 pathway plays an important role in the pancreatic beta-cell apoptosis that is observed in STZ-induced type 1 diabetes; however, the upstream regulatory proteins involved have not been understood. Here, we investigated whether activating transcription factor 3 (ATF3) affe...

journal_title：Cellular signalling

authors： Kim JY,Song EH,Lee S,Lim JH,Choi JS,Koh IU,Song J,Kim WH

更新日期：2010-11-01 00:00:00

abstract：:Mycophenolic acid (MPA), widely used to prevent organ transplant rejection, may induce toxicity and impair function in beta-cells. Mechanisms of MPA-induced cell death have not been fully explored. In this study, we examined gene expression patterns in INS-1E cells and isolated primary rat islets following MPA treatme...

journal_title：Cellular signalling

authors： Park YJ,Ahn HJ,Kim YS,Cho Y,Joo DJ,Ju MK

更新日期：2010-11-01 00:00:00

abstract：:The mammalian target of rapamycin complex 1(mTORC1) integrates diverse signals to control cell growth, proliferation, survival, and metabolism. Role of reactive oxygen species (ROS) on mTORC1 signaling remains obscure and mechanisms through which ROS modulate mTORC1 are not known.We demonstrate that low doses ROS expo...

journal_title：Cellular signalling

authors： Li M,Zhao L,Liu J,Liu A,Jia C,Ma D,Jiang Y,Bai X

更新日期：2010-10-01 00:00:00

abstract：:Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative multifactorial disease characterized, like other diseases such as Alzheimer's disease (AD), Parkinson's disease (PD) or frontotemporal dementia (FTD), by the degeneration of specific neuronal cell populations. Motor neuron loss is distinctive of ALS. However, ...

journal_title：Cellular signalling

authors： Cova E,Ghiroldi A,Guareschi S,Mazzini G,Gagliardi S,Davin A,Bianchi M,Ceroni M,Cereda C

更新日期：2010-10-01 00:00:00

abstract：:High levels of VEGF and leptin are strongly linked to worse prognosis of breast cancer. Leptin signalling upregulates VEGF in human and mouse mammary tumor cells (MT), but the specific molecular mechanisms are largely unknown. Pharmacologic and genetic approaches were used to dissect the mechanism of leptin regulation...

journal_title：Cellular signalling

authors： Gonzalez-Perez RR,Xu Y,Guo S,Watters A,Zhou W,Leibovich SJ

更新日期：2010-09-01 00:00:00

abstract：:Regulators of G protein signalling (RGS) proteins are united into a family by the presence of the RGS domain which serves as a GTPase-activating protein (GAP) for various Galpha subunits of heterotrimeric G proteins. Through this mechanism, RGS proteins regulate signalling of numerous G protein-coupled receptors. In a...

journal_title：Cellular signalling

authors： Sethakorn N,Yau DM,Dulin NO

更新日期：2010-09-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress activated by perturbations in ER homeostasis induces the unfolded protein response (UPR) with chaperon Grp78 as the key activator of UPR signalling. The aim of UPR is to restore normal ER function; however prolonged or severe ER stress triggers apoptosis of damaged cells to ensure pro...

journal_title：Cellular signalling

authors： Kyriakakis E,Philippova M,Joshi MB,Pfaff D,Bochkov V,Afonyushkin T,Erne P,Resink TJ

更新日期：2010-09-01 00:00:00

abstract：:Slug, a Snail-related zinc-finger transcription factor implicated in the increased motility of mesenchymal cells during embryonic development and progression of cancer cells towards an invasive phenotype, plays a specific and critical role in the pathogenesis of Bcr-Abl-associated leukemias. Here we report that Slug o...

journal_title：Cellular signalling

authors： Mancini M,Petta S,Iacobucci I,Salvestrini V,Barbieri E,Santucci MA

更新日期：2010-08-01 00:00:00

abstract：:p21(Waf1/Cip1/Sdi1) was originally identified as an inhibitor of cyclin-dependent kinases, a mediator of p53 in growth suppression and a marker of cellular senescence. p21 is required for proper cell cycle progression and plays a role in cell death, DNA repair, senescence and aging, and induced pluripotent stem cell r...

journal_title：Cellular signalling

authors： Jung YS,Qian Y,Chen X

更新日期：2010-07-01 00:00:00

abstract：:Extracellular signal regulated kinases (ERKs) are a class of MAP kinases that function in many signaling pathways in eukaryotic cells and in some cases, a single stimulus can activate more than one ERK suggesting functional redundancy or divergence from a common pathway. Dictyostelium discoideum encodes only two MAP k...

journal_title：Cellular signalling

authors： Nguyen HN,Raisley B,Hadwiger JA

更新日期：2010-05-01 00:00:00

abstract：:Sustained activation of Akt kinase acts as a focal regulator to increase cell growth and survival, which causes tumorigenesis including breast cancer. Statins, potent inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, display anticancer activity. The molecular mechanisms by which statins block cancer cell ...

journal_title：Cellular signalling

authors： Ghosh-Choudhury N,Mandal CC,Ghosh-Choudhury N,Ghosh Choudhury G

更新日期：2010-05-01 00:00:00

abstract：:The pro-apoptotic protein BIM(EL) is phosphorylated by ERK1/2 and this targets the protein for poly-ubiquitination and degradation by the proteasome as a survival mechanism. To define in greater detail the sequence determinants required for BIM(EL) turnover we have compared various BIM splice variants and truncation m...

journal_title：Cellular signalling

authors： Wiggins CM,Johnson M,Cook SJ

更新日期：2010-05-01 00:00:00

abstract：:Insulin is an inducer of brown fat adipogenesis through the activation of a signalling network that involves positive/negative modulators. Given the importance of brown adipose tissue (BAT) for basal thermogenic energy expenditure, we investigated the role of PTP1B in the acquisition of terminal differentiated phenoty...

journal_title：Cellular signalling

authors： Miranda S,González-Rodríguez A,Revuelta-Cervantes J,Rondinone CM,Valverde AM

更新日期：2010-04-01 00:00:00

abstract：:Cellular hypoxia can lead to cell death or adaptation and has important effects on development, physiology, and pathology. Here, we investigated the role and regulation of ceramide in hypoxia-induced apoptosis of SH-SY5Y neuroblastoma cells. Hypoxia increased the ceramide concentration; subsequently, we observed bioch...

journal_title：Cellular signalling

authors： Kang MS,Ahn KH,Kim SK,Jeon HJ,Ji JE,Choi JM,Jung KM,Jung SY,Kim DK

更新日期：2010-04-01 00:00:00

abstract：:Desensitization of the micro-opioid receptor (MOR) has been implicated as an important regulatory process in the development of tolerance to opiates. Monitoring the release of intracellular Ca(2+) ([Ca(2+)](i)), we reported that [D-Ala(2), N-Me-Phe(4), Gly(5)-ol]-enkephalin (DAMGO)-induced receptor desensitization req...

journal_title：Cellular signalling

authors： Chu J,Zheng H,Zhang Y,Loh HH,Law PY

更新日期：2010-04-01 00:00:00

abstract：:CD45 is a leukocyte specific transmembrane glycoprotein and a receptor-like protein tyrosine phosphatase (PTP). CD45 can be expressed as several alternatively spliced isoforms that differ in the extracellular domain. The isoforms are regulated in a cell type and activation state-dependent manner, yet their function ha...

journal_title：Cellular signalling

authors： Saunders AE,Johnson P

更新日期：2010-03-01 00:00:00

abstract：:The molecular mechanisms that underlie non-genomic induction of the 25-hydroxyvitamin D3 24-hydroxylase (CYP24) gene promoter by the steroid hormone, 1,25-Dihydroxyvitamin D3 (1,25D), are poorly understood. Although we have previously identified a functional inverted GC-box in the early promoter at -113/-105 bp, it is...

journal_title：Cellular signalling

authors： Dwivedi PP,Gao XH,Tan JC,Evdokiou A,Ferrante A,Morris HA,May BK,Hii CS

更新日期：2010-03-01 00:00:00

abstract：:Endothelin-1 (ET-1) is a vasoconstrictor peptide known to be a potent mitogen for glomerular mesangial cells. We have shown that ET-1 stimulates the adaptor protein p66Shc through Rac/Cdc42 guanine nucleotide exchange factor beta(1)Pix. In this study, we demonstrate that ET-1-induced serine phosphorylation of p66Shc i...

journal_title：Cellular signalling

authors： Chahdi A,Sorokin A

更新日期：2010-02-01 00:00:00

abstract：:The ectodomain of TOLL-like receptors (TLR) is highly glycosylated with several N-linked gylcosylation sites located in the inner concave surface. The precise role of these sugar N-glycans in TLR receptor activation is unknown. Recently, we have shown that Neu1 sialidase and not Neu2, -3 and -4 forms a complex with TL...

journal_title：Cellular signalling

authors： Amith SR,Jayanth P,Franchuk S,Finlay T,Seyrantepe V,Beyaert R,Pshezhetsky AV,Szewczuk MR

更新日期：2010-02-01 00:00:00

abstract：:The human ether-a-go-go related gene (HERG) potassium channel has elicited intense scientific interest due to its role in cardiac repolarization and its association with arrhythmia and sudden cardiac death. Increasing evidence indicates the involvement of HERG channels in the pathophysiology of cancer. In the present ...

journal_title：Cellular signalling

authors： Afrasiabi E,Hietamäki M,Viitanen T,Sukumaran P,Bergelin N,Törnquist K

更新日期：2010-01-01 00:00:00

abstract：:Stathmin is overexpressed in a variety of assessed human malignancies and is correlated with tumor progression and poor prognosis. Downregulation of its expression will contribute to optimize therapeutic outcomes in the treatment of various malignancies. However, the mechanisms of stathmin gene overexpression are not ...

journal_title：Cellular signalling

authors： Fang L,Min L,Lin Y,Ping G,Rui W,Ying Z,Xi W,Ting H,Li L,Ke D,Jihong R,Huizhong Z

更新日期：2010-01-01 00:00:00

abstract：:Unc119 is an adapter signaling molecule, which regulates activation of tyrosine kinases in T cells, eosinophils and fibroblasts. It plays an important role in the photoreceptor synapses of the retina. Recently, we have shown that it inhibits bacterial uptake through macropinocytosis. In this paper we demonstrate a rol...

journal_title：Cellular signalling

authors： Karim Z,Vepachedu R,Gorska M,Alam R

更新日期：2010-01-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) and its ether analog alkyl-glycerophosphate (AGP) elicit arterial wall remodeling when applied intralumenally into the uninjured carotid artery. LPA is the ligand of eight GPCRs and the peroxisome proliferator-activated receptor gamma (PPARgamma). We pursued a gene knockout strategy to iden...

journal_title：Cellular signalling

authors： Cheng Y,Makarova N,Tsukahara R,Guo H,Shuyu E,Farrar P,Balazs L,Zhang C,Tigyi G

更新日期：2009-12-01 00:00:00

abstract：:We have previously demonstrated that inhibition of calmodulin (CaM) and the concomitant reduction of PI3K interfere with H-Ras-mediated activation of Raf-1 [1]. In the present study, we show that CaM has completely opposite effects on K-Ras-mediated Raf-1 activation. The differential contribution of CaM in the regulat...

journal_title：Cellular signalling

authors： Moretó J,Vidal-Quadras M,Pol A,Santos E,Grewal T,Enrich C,Tebar F

更新日期：2009-12-01 00:00:00

abstract：:Netrin-1 attracts or repels growing axons during development. The UNC5 receptors mediate the repulsive response, either alone or in complex with DCC receptors. The signaling mechanisms activated by UNC5 are poorly understood. Here, we examined the role of Rho GTPases in UNC5a signaling. We found that UNC5a induced neu...

journal_title：Cellular signalling

authors： Picard M,Petrie RJ,Antoine-Bertrand J,Saint-Cyr-Proulx E,Villemure JF,Lamarche-Vane N

更新日期：2009-12-01 00:00:00

abstract：:Here we demonstrate that elevation of cyclic AMP (cAMP) levels in human umbilical vein endothelial cells (HUVECs) specifically attenuates ERK1,2 activation in response to either leptin or a soluble interleukin IL-6 receptor-alpha/IL-6 (sIL-6R alpha/IL-6) trans-signalling complex but not protein kinase C activator phor...

journal_title：Cellular signalling

authors： Woolson HD,Thomson VS,Rutherford C,Yarwood SJ,Palmer TM

更新日期：2009-11-01 00:00:00

abstract：:The D405N and Y546F mutations of the human lutropin receptor (hLHR) have previously been shown to partially attenuate hCG-stimulated cAMP synthesis despite normal cell surface expression and hCG binding affinity (Min, L. and Ascoli, M. Mol. Endocrinol. 14:1797-1810, 2000). We now show that these mutations each stabili...

journal_title：Cellular signalling

authors： Zhang M,Feng X,Guan R,Hébert TE,Segaloff DL

更新日期：2009-11-01 00:00:00